Wednesday, April 10, 2013

Sodium channel review gets top ranking in Biophys J in 2012

Friends of the lab, Filip, Paolo and I, recently put together a review on the regulation of sodium channels by intracellular calcium ions.  Like all channel fields trying to study modulation, things are a bit tricky.  These physiological tweaks of channel gating, wether it be (dreaded) phosphorylation or any other labile modification of channels, Ca2+ regulation of sodium channels has been a function enigma since its initial description.  Simply put, scientists see variable functional effects on channel gating when intracellular calcium levels are varied.  We did our best to summarize these different results and propose a novel mechanism of channel facilitation.  Check out the details here.

1 comment:

  1. Fascinating paper and the lobe switching model is intriguing. I have wondered if sodium channel inactivation might also be triggered at some point between sodium channels, via some sort of interlinking moiety. Some discussion of the idea here.
    Regards, John Harris