Wednesday, November 10, 2010

Congrats to the Van Petegem Lab!

We can't always have all the fun with our own publications so it gives me great pleasure to congratulate the neighboring lab of collaborator Dr. Filip Van Petegem for his Nature paper this week. Filip and his crew have been tackling the structural challenges of the biggest ion channel of them all, the 2.5 megadalton beast known as the Ryanodine Receptor. This structure of this channel is of interest (and importance) because it controls calcium release in skeletal and cardiac muscle. In this weeks issue of Nature, Filip presents a high resolution crystal structure the biggest piece of the N-terminal domain of the channel to date which highlights a hot-spot of cardiovascular mutations. Way to go on a beautiful bit of science.

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